Request for proposal RFP - 027286 - EVALUATION OF COMBINATION THERAPY INVOLVING A TEST COMPOUND AND A SELECTED STANDARD-OF-CARE AGENT IN THREE-DIMENSIONAL CANCER MODELS WITH CONSIDERATION OF THE IMMUNE MICROENVIRONMENT 

In connection with the project „Clinical trial of the first phase (Ia/Ib) of a fusion protein with a dual anticancer mechanism”, financed from Medical Research Agency (nr. 2022/ABM/05/00006-00)operating under §8 of the subsidy agreement, Adamed Pharma S.A.  invites you to submit offers for the execution of the below defined subject of the contract. 

Study Sponsor (Contracting Authority): Adamed Pharma S.A. 

Subject of Order

1. The objective of the procurement is to evaluate the effect of combination therapy involving a test compound and a selected standard-of-care agent  in three-dimensional cancer models, in the presence or absence of the immune microenvironment. As part of the contract, three-dimensional culture models will be developed and validated for either eight or four cell lines, followed by studies including cell viability analysis, determination of dose–response curves (IC50/GR50), and assessment of the expression of selected molecular markers. A detailed description of the scope of work and tasks is provided in Appendix No. 7. 

   The test compound in the required quantities will be provided by the Contracting Authority. All other reagents and materials necessary for the completion of the full scope of the study shall be provided by the Contractor, and their costs shall be included in the cost estimate. Project progress will be reported through update meetings with the Contracting Authority, following which meeting minutes or a presentation summarizing the discussed topics will be provided. 

   The expected timeframe for preparing the final reports for all tasks is Q4 2026 – Q1 2027. 

   The Contracting Authority does not allow the submission of partial bids, i.e. bids covering only selected tasks. 

   The required study deliverables, including the reports specified in Appendix No. 7 and other electronic files (e.g. photographic documentation), shall be delivered in electronic form and made available via a secure data repository of the SharePoint type designated by the Contracting Authority, with access restricted exclusively to authorized users. 

Conditions for participation in the proceedings

1. The contract may not be awarded to entities related to the Ordering Party personally or by capital. Capital or personal ties are understood as interrelationships between the Ordering Party and the Supplier or persons authorized to incur liabilities on behalf of the Ordering Party or persons performing on behalf of the Ordering Party activities related to the preparation and conduct of the Supplier selection procedure, consisting in particular of:
   1. participating in the company as a partner in a civil partnership or partnership, 
   2. owning at least 10% of shares or stocks, 
   3. acting as a member of the supervisory or management body, proxy, proxy, 
   4. remaining in a marriage, relationship of kinship or affinity in a straight line, kinship of the second degree or affinity in the lateral line or in relation to adoption, care or guardianship. 
   5. being in such a legal or factual relationship with the contractor that there is a justified doubt as to their impartiality or independence in connection with the procurement procedure. 
      In order to meet this condition, the Supplier is obliged to send, together with the offer, a signed Statement on the lack of connections (Appendix no. 1 to this RFP). 
2. Orders cannot be awarded to:
   1. a Contractor referred to art. 7 sec. 1 indicated in lists specified in Regulation no 765/2006 and Regulation no 269/2014 or entered in list on basis of a decision on entry in the list deciding on application of measure referred to article 1 point 3 of the Act of April 13, 2022 on special solutions in field of counteracting supporting aggression against Ukraine (Polish Journal of Laws no 835).
   2. a Contractor whose beneficial owner within meaning of the Act of 1 March 2018 on counteracting money laundering and financing terrorism (Polish Journal of Laws no 593 and 655) is a person indicated in lists specified in Regulation 765/2006 and the Regulation 269/2014 or entered on  list or being such a beneficial owner from February 24, 2022, provided that it was entered on list on the basis of a decision on entry in the list determining application of measure referred to in art. 1 point 3 of the Act of April 13, 2022 on special solutions in field of counteracting supporting aggression against Ukraine (Polish Journal of Laws no 835);
   3. a Contractor whose parent undertaking or subsidiary entity within the meaning of Art. 3 sec. 1 point 37 and 39 of the Accounting Act of 29 September 1994 (Polish Journal of Laws no 217, 2105 and 2106) is an entity indicated in the lists specified in Regulation 765/2006 and Regulation 269/2014 or entered on the list or being such a parent undertaking from February 24, 2022, provided that it was entered on list on the basis of a decision on entry in list determining application of measure referred to in art. 1 point 3 of the Act of April 13, 2022 on special solutions in field of counteracting supporting aggression against Ukraine (Polish Journal of Laws no 835).
      In order to meet this condition, the Supplier is required to submit a signed sanctions declaration (Appendix 2) to this request for proposals along with the offer.
3. This offer is addressed to entities with proven experience in providing similar services. The required experience shall be demonstrated by submitting a declaration of compliance with the requirements specified below, constituting Appendix No. 3 to this Request for Proposal. 
   1. A minimum of three (3) years of documented experience in the development and validation of proliferation assays in three-dimensional (3D) co-culture systems involving cancer cells and PBMCs. 
   2. Demonstrated capability to work with biologically complex molecules (e.g. multifunctional and multidomain compounds) and to perform assays based on specific mechanisms of action. 
   3. Proven experience and appropriate technical infrastructure enabling the design, execution, and analysis of synergy and additivity assays involving two biologically active compounds, including compounds modulating the immune response. 
      The Ordering Party reserves the right to request the Bidder to submit additional documents and explanations confirming the information provided in the declaration (Appendix No. 3). 

Method of preparing the offer 

1. Each correspondence should include the number of the procedure in the subject line:  
   RFP 027286- Evaluation of combination therapy involving a test compound and a selected standard of care agent in three-dimensional cancer models with consideration of the immune microenvironment - Company name / Name 
2. Deadline for submitting offer is 24.02.2026 at 23:59. The date may change, about which all Suppliers will be informed. 
3. The offer should contain at least the following information: Company name, address, VAT/registry number, number of the inquiry, net price, currency, payment terms (in days) and required appendices. 
4. If prices in offer are expressed in a currency other than PLN, will be converted using the average exchange rate of the National Bank of Poland as of the date of publication of the tender. If the table of average NBP exchange rates is not published on the date of publication, the exchange rate from the last table of average exchange rates published before the date of publication of the contract notice will be used. 
5. The cost estimate should be prepared in a spreadsheet file, attached as Appendix no. 4 to this request for proposal: Appendix_4_RFP_027286_Cost proposal. In addition, the Bidder may prepare the bid in its own format. Bids without a completed Attachment No. 4 will not be considered. 
6. Questions should be submitted via the Adamed Procurement Platform SAP Ariba Network or sent via e-mail to: aleksandra.stojak@adamed.com, using the sheet Appendix no. 5. The Ordering Party reserves the right not to provide a response in the event that the question(s) are submitted within two days prior to the end of the tender procedure. In order to ensure equal access to information to all Tenderers participating in the procedure, questions and answers (concealing the author of the questions) will be sent to all Tenderers and published on the Ordering Party’s website.  
7. All required annexes, declarations, and documents must be attached to the offer. The Ordering Party also includes with the request a completed and signed checklist (Appendix No. 6), which will serve to confirm whether all required documents have been submitted. 
8. The offer with all appendices can be placed on Adamed Procurement Platform SAP Ariba Network at https://supplier.ariba.com or sent via e-mail to: aleksandra.stojak@adamed.com. 
9. Each Tenderer may submit only one offer  
10. The Ordering Party does not allow partial offers  
11. The Proposal should be prepared in Polish or English  
12. Tenders submitted after the deadline will not be considered  
13. The Supplier before time-limit for receipt of tenders is entitled: 
    a. to withdraw the offer by written notification by e-mail indicated for the submission of tenders,  
    b. to change the offer – notification of the changes must be submitted by the same rules as the submitted offer, appropriately marked with the note "CHANGING THE OFFER".  

Evaluation of submitted offers and selection criteria

1. The Contracting Authority is entitled to reject the tender submitted by the Supplier who does not meet the conditions for participation in the proceedings, or if the offer is incomplete or incompatible with this request. 

2. Selection criteria:

   1. Net price presented as the cost of performing individual parts of the service package - criterion weight: 100% of the overall score, including all costs of the service provided 
3. The Ordering Party shall evaluate offers based on the results of accumulated number of points calculated on the basis of above criteria and scores

4. Criteria	Weight [%]	Assessment method according to the formula
   Net price	100%	net price of the lowest offer / net price of the examined offer  x 100 x weight % = number of points  Refers to the sum of the component items indicated in the Cost Estimate

5. The Ordering Party reserves the right to negotiate proposals with all the Bidders. Negotiations may have several consecutive rounds with the possibility to invite the Bidders to submit the updated quotation after each round of negotiations
6. The offer with the highest final number of points will be considered the most advantageous 
7. The results of mathematical operations performed when evaluating the bids are rounded to two decimal places. In the event that at least two tenders receive the same score, the Contracting Authority shall select from among the tenders with the highest final score, the tender that is more advantageous in terms of environmental impact. For this purpose, the Contracting Authority reserves the right to request the tenderers whose tenders achieved the highest final score to supplement their tenders by providing information specified by the Contracting Authority regarding the environmental impact of the subject matter of the tender. The deadline for submitting such supplementary information shall be set by the Contracting Authority and shall not be shorter than three (3) business days from the date of receipt of the request.   

Selection of the Contractor and manner of announcement

1. The Ordering Party will select the most advantageous offer on the basis of the offer evaluation criteria specified in this inquiry. 
2. The Ordering Party will inform about the results of this inquiry on the website  https://www.adamed.com/en/development-and-innovation/requests-for-proposals-and-tenders and will send them via SAP Ariba Platform to each Supplier who has submitted his offer. 

Additional Information Regarding Participation in the Procedure

1. The Request for Quotation is available on the Adamed Group Procurement Platform at https://supplier.ariba.com and on the Adamed Pharma S.A. website: https://www.adamed.com/. 
2. Login credentials required to access the Procurement Platform will be provided to Suppliers by the Operator via e-mail. 
3. Technical requirements: To work smoothly with the Procurement Platform (https://supplier.ariba.com), users should have at least the following technical capabilities: 
   1. A PC or MAC computer with a 1 GHz processor or faster and a minimum of 512 MB RAM, 
   2. A stable Internet connection with a guaranteed bandwidth of at least 1 Mb/s, 
   3. The latest version of a web browser: IE 9.0+, Mozilla Firefox 24+, Chrome 26+, or Safari 5+. 
4. The procedure will only be repeated in the event that it cannot be conducted due to reasons attributable to the Operator or the Contracting Authority. Technical issues on the part of the Suppliers will not affect the course of the procedure. 
5. Before participating in the procedure, it is recommended to review the User Guide for the Procurement Platform attached to this procedure. 
6. The start and end dates as well as the configuration of each stage of the procedure will be presented on the Procurement Platform and may be subject to change; all interested Suppliers will be promptly notified by e-mail through the system. 
7. During the procedure, Suppliers may contact technical support at +48 539 737 818 or through the Help section in the platform application. 

General provisions

1. By submitting a tender, the Tenderer declares that the offer shall remain valid for a period of 90 days. 
2. The contracting authority reserves the right to cancel the procedure without giving any reason at any stage of the procedure. 
3. In the event of cancellation of the procurement procedure, the contractors shall not be entitled to claim reimbursement of the costs of participation in the procedure. 
4. By submitting an offer, you accept all terms and conditions of the procedure without any reservations. 
5. Withdrawal by the Ordering Party from concluding the contract in the event of notifying the contractor about the selection of its offer, it may not be the basis for claims for the costs of participation in the procedure. 
6. In the course of assessing the submitted applications, the Ordering Party may request the contractors to provide explanations regarding the content of the documents submitted by them. 
7. If the offer does not contain all the required elements, the Ordering Party may, in justified cases, call the Contractor to supplement it. 
8. The contracting authority reserves the right to record sound during technical meetings with suppliers. Sending the offer will be treated as giving consent to record the meetings. 
9. The Bidder's withdrawal from the conclusion of the contract upon notification of the contractor about the selection of their offer may serve as a basis for the Ordering Party's claims, including those related to the damages incurred (such as delays resulting from the necessity to choose another contractor). In such cases, the provisions of the Civil Code shall apply accordingly. Therefore, the Ordering Party requests that thoughtful offers be submitted, in compliance with all the expected conditions of the order, taking into account the indicated foreseeable deadlines for its execution. 
10. It is possible to place additional orders exclusively to the selected Bidder, if they align with the main objective of this agreement, with a value not exceeding 50% of the value of this order. 
11. The Ordering party will sign a contract with the selected Contractor.  
12. The Ordering Party does not undertake to purchase a specific number of services from the selected Supplier. The Ordering Party will order services from the selected Supplier only if a need for such services arises in the Ordering Party during the contract period. Services will be provided on the basis of orders placed according to the Ordering Party's current needs. 
13. The Ordering Party provides for the possibility of introducing significant changes to the contract concluded as a result of the conducted contract award procedure in relation to the content of the offer, on the basis of which the contractor was selected, in the event of the necessity to change the scope of service indicated in the offer / agreed scope, resulting from: 
    1. justified and required changes in the project documentation that were impossible to predict at the time of contract execution 
    2. the necessity or technical and economic justification for the use of equivalent materials and equipment 
    3. the necessity to implement equivalent solutions resulting from technological or operational conditions 
    4. financial limitations of Ordering Party resulting in limiting the scope of contracted activities 
    5. in the event of an unforeseen necessity, not anticipated at the tender stage, to carry out additional services/analyses due to their scientific nature and the resulting complexity that is difficult to predict, the Parties allow for the possibility of extending the execution deadline. Any extension of the deadline requires prior written approval from the Sponsor. 
       Any changes and additions to the contract concluded with the selected Contractor will be made in the form of written annexes to the contract signed by both parties 

Cooperation and communication in the course of preparing responses 

1. All questions related to the subject of this inquiry may be directed via the Adamed Group Purchasing Platform at: https://supplier.ariba.com or via email to: aleksandra.stojak@adamed.com, using an Excel file - Appendix No 5. 
2. The list of required documents is available in Appendix No. 6.
3. The person authorized to contact the Suppliers on Monday-Friday from 08:00 am to 16:00 is  Aleksandra Stojak: [aleksandra.stojak@adamed.com]. 

Appendix No 1  (download)

Appendix No 2  (download)

Appendix No 3  (download)

Appendix No 4  (download)

Appendix No 5  (download)

Appendix No 6  (download)

Appendix No 7  (download)

SAP Ariba Supplier’s user guide - SAP Ariba Network registration (download)

Supplier's instructions - Creating an offer on the Portal SAP Ariba Network (download)