Biotechnology Lab

Biotechnology Lab

The Biotechnology Lab is responsible for developing protein production processes as part of Adamed’s innovative research programmes. The Lab’s tasks include optimisation of the following protein manufacturing stages: designing DNA constructs coding the target molecules, selection of bacterial strains and expression vectors, establishing the optimal conditions for expression, and scaling the manufacturing process.

The Lab is equipped with a state-of-the-art apparatus which enables the development of effective production processes for drug candidates in bacterial expression systems. The team uses New Brunswick fermenters with a capacity of 4 to 35 litres which enable complete software-level control over the process.

Also, mammalian expression systems have been implemented in the Lab on a laboratory scale to produce small batches of monoclonal antibodies and their fragments. Equipped with Class 2 laminar cabinets, incubators, and a Kuhner LT-X (Lab-Therm) incubator shaker, the Lab can grow cultures of both adherent and highly-efficient cells in the production of recombinant proteins in suspension-cultured cells. It can optimise the entire process in a scale of up to several litres.

Last year, the Phage Display technique was implemented which enables the staff to select antibody fragments and use them in targeted therapy.