The Biotechnology Lab is responsible for developing protein production processes as part of Adamed’s innovative research programmes. The Lab’s tasks include optimisation of the following protein manufacturing stages: designing DNA constructs coding the target molecules, selection of bacterial strains and expression vectors, establishing the optimal conditions for expression, and scaling the manufacturing process.
The Lab is equipped with a state-of-the-art apparatus which enables the development of effective production processes for drug candidates in bacterial expression systems. The team uses New Brunswick fermenters with a capacity of 4 to 35 litres which enable complete software-level control over the process.
Also, mammalian expression systems have been implemented in the Lab on a laboratory scale to produce small batches of monoclonal antibodies and their fragments. Equipped with Class 2 laminar cabinets, incubators, and a Kuhner LT-X (Lab-Therm) incubator shaker, the Lab can grow cultures of both adherent and highly-efficient cells in the production of recombinant proteins in suspension-cultured cells. It can optimise the entire process in a scale of up to several litres.
Last year, the Phage Display technique was implemented which enables the staff to select antibody fragments and use them in targeted therapy.