The Preformulation Department studies the physical properties of active ingredients, excipients, and finished formulations. These studies are crucial for designing further formulation work based on scientific evidence.
The department uses a variety of research methods: scanning electron microscopy, optical microscopy combined with digital image analysis, confocal Raman microscopy, XRPD, DSC, TGA, DVS (dynamic vapour sorption), IR, texture analysis, BET specific surface area analysis, and true density.
These techniques are used to study the crystal structure, mechanical properties, size and shape of molecules, physical incompatibilities, specific area, and hygroscopicity of substances, among other applications.
Studies conducted at the Preformulation Department provide information that determines the course of the formulation process, and thus the stability and behaviour of the product in vivo.
The creativity of the staffmeans that non-standard approaches to test planning are often taken[MS1] . This strategy allows us to precisely identify the properties and the interactions between substances in the finished formulation. The knowledge gained in this process is crucial for understanding the biopharmaceutical properties of the product to ensure that the finished formulation is of the highest quality.