Formulation & Technology Department

Formulation & Technology Department

The Formulation and Technology Department is the unit responsible for technological development to select optimal formulas and manufacturing techniques for solid and liquid dosage forms. The laboratory zone is a state-of-the-art facility equipped with dedicated lines for mixing, dry, wet, and fluid-bed granulation, extrusion, pelletization, tableting, coating, and encapsulation.
The equipment available for laboratory development enables the formulation of test batches with sizes ranging from a few hundred grams to a few kilograms, and is the same as at the Pilot Plant, where further process scale-up and optimization are performed. Qualitatively identified products and processes are implemented on the production lines at Adamed Pharma’s drug manufacturing plants in Pabianice and Ksawerów.
Formulation research is conducted in ongoing collaboration with the preformulation, analytics, and organic synthesis departments, patent attorneys, manufacturing process engineers, as well as internal and external clinical experts. As a result of this collaboration, unique and technologically advanced therapies are developed, usually containing two or three active pharmaceutical ingredients that give patients access to state-of-the-art medicines of proven quality.
In addition to developing traditional solid dosage forms including granulates, powders, coated and uncoated tablets, modified release products, and hard capsules, the Formulation & Technology Department focuses on novel complex dosage forms, such as multilayer tablets or multi-dose capsules.
A new research platform in the area is the Respiratory Laboratory, where inhalational medicinal products are developed. Projects in the pipeline are implemented in a cutting-edge technological and analytical zone equipped with lines dedicated to the dosage forms in development (e.g. dry powder capsules for inhalation, disks) and a full range of analytical equipment. The new research platform supports the scale-up of inhaled drugs from laboratory to pilot-scale as well as full physicochemical and chromatographic characterization based the highest standards for handling HP ingredients.