REQUEST FOR PROPOSAL RFP 022897 – SYNTHESIS AND OPTIMIZATION OF POLYOLIGONUCLEOTIDES IN TERMS OF EFFICIENT PRODUCTION IN DIFFERENT EXPRESSION SYSTEMS

In connection with the co-financing of the project entitled „Development of novel mRNA/VLP-based vaccines against emerging zoonotic viral diseases” financed by the State budget from the Medical Research Agency (no. 2021 / ABM / 05 / 00001-00) as part of the Competition: Development of innovative therapeutic solutions using RNA technology, pursuant to § 8 sec. 2 point 2) of the co-financing agreement, Adamed Pharma S.A.. invites to submit tenders for the below-defined service.

Subject of the Tender:

SYNTHESIS AND OPTIMIZATION OF POLYOLIGONUCLEOTIDES IN TERMS OF EFFICIENT PRODUCTION IN DIFFERENT EXPRESSION SYSTEMS

Study Sponsor (Contracting Authority): Adamed Pharma S.A.

On order, the execution of which was carried out until December 31, 2024, how are the tasks:

1. Synthesis of genes of any length

• a synthesized gene of any length cloned into a standard vector (provided free of charge by the tenderer) carrying an antibiotic resistance gene (ampicillin, kanamycin and possibly others)
• The minimum amount of the obtained plasmid containing the synthesized gene - 5 µg
• Form of delivery - purified and lyophilized plasmid with qualitative documentation confirming the insert sequence: order details, vector information, DNA sequence in FASTA format, gene sequencing chromatogram
• Possibility of cloning to the selected plasmid provided by the Ordering Party.
• Delivery time: up to 10 working days for simple genes or up to 25 working days for complex genes
• Possibility to place partial orders for single genes

Place of delivery: Adamed Pharma SA, Pieńków, Mariana Adamkiewicza 6A, 05-152 Czosnów.

Conditions for participation in the proceedings:

1. Orders cannot be awarded to entities affiliated personally of financially with the Contracting Authority. Through financial or personal connection we understand the interactions between the Contracting Authority or persons authorized to enter into commitments on behalf of the Contracting Authority or persons performing on behalf of the Purchaser activities associated with the preparation and the procedure for selecting Suppliers and Supplier, in particular by:
   1. participation in the company as a partner or partnership,
   2. owning at least 10% of the shares,
   3. the functions of a member of the supervisory or management, proxy,
   4. remaining married in consanguinity or affinity in a straight line, second-degree consanguinity or affinity of the second degree in the collateral line or by adoption or guardianship.
      ​In order to fulfill this condition a Tenderer is obliged to send with the offer signed statements about the lack of connections (Appendix no 1 to this RFP).
2. Orders cannot be awarded to:
   1. a contractor referred to art. 7 sec. 1 indicated in lists specified in Regulation no 765/2006 and Regulation no 269/2014 or entered in list on basis of a decision on entry in the list deciding on application of measure referred to article 1 point 3 of the Act of April 13, 2022 on special solutions in field of counteracting supporting aggression against Ukraine (Polish Journal of Laws no 835).
   2. a contractor whose beneficial owner within meaning of the Act of 1 March 2018 on counteracting money laundering and financing terrorism (Polish Journal of Laws no 593 and 655) is a person indicated in lists specified in Regulation 765/2006 and the Regulation 269/2014 or entered on  list or being such a beneficial owner from February 24, 2022, provided that it was entered on list on the basis of a decision on entry in the list determining application of measure referred to in art. 1 point 3 of the Act of April 13, 2022 on special solutions in field of counteracting supporting aggression against Ukraine (Polish Journal of Laws no 835);
   3. a contractor whose parent undertaking or subsidiary entity within the meaning of Art. 3 sec. 1 point 37 and 39 of the Accounting Act of 29 September 1994 (Polish Journal of Laws no 217, 2105 and 2106) is an entity indicated in the lists specified in Regulation 765/2006 and Regulation 269/2014 or entered on the list or being such a parent undertaking from February 24, 2022, provided that it was entered on list on the basis of a decision on entry in list determining application of measure referred to in art. 1 point 3 of the Act of April 13, 2022 on special solutions in field of counteracting supporting aggression against Ukraine (Polish Journal of Laws no 835).
      In order to fulfill this condition a Tenderer is obliged to send with the offer signed statement (Appendix no 2 to this RFP).
3. This offer is addressed to entities:

• with competent staff operating the equipment for polyoligonucletide synthesis and DNA sequencing, having appropriate higher education in the field (biological or chemical and IT).
• The entity must have a minimum of 3 years of experience in the commercial use of DNA synthesis and analysis techniques,
  These requirements should be confirmed in the form of statements, references or CVs of the staff.
• have a platform or website with the following features;

1. Ability to log in securely to a password-protected account
2. Possibility to include a nucleotide or protein sequence
3. Possibility to name the ordered gene
4. Possibility to add any sequence for 3 'and 5' sequences
5. Ability to add any restriction enzyme cleavage site
6. Possibility to eliminate specific motifs (e.g. restriction sites) in the synthesized gene or specific nucleotide sequences
7. A unique algorithm that allows optimization of the sequence in terms of expression in a specific expression system (minimum: human, hamster, E. coli, yeast: S. cerevisiae, P. pastoris) and minimization of the formation of unfavorable secondary and tertiary structures, optimization of the content of GC pairs in the nucleotide sequence, elimination of non-specific binding sites of transcription factors, and elimination of splicing sites
8. Possibility to block the optimization of a specific fragment of a polyoligonucleotide
The Tenderer is obliged to send an appropriate statement proving that the criterion in question has been met.

Supplementary orders may be submitted to the selected Tenderer only if they are consistent with the main purpose of this contract, with a value not exceeding 50% of the value of this contract.

Terms and methods of offer submission 

1. The title of each correspondence should include the number of the procedure

   RFP 022897– Company name

   Deadline for submitting Offer is 17-11-2022 at 23:59 CEST. The deadline may change, all Suppliers will be informed by e-mail from the Procurement System. 

   Questions should be submitted using the sheet Appendix_3_RFP_022897_Questions_ [Company Name]. Questions will be answered until the end of the procedure. Late submission of questions from the point of view of the closing date of the procedure may result in a lack of time to provide the required answer. In order to ensure equal access to information to all Bidders participating in the procedure, questions and answers (concealing the author of the questions) will be sent to all Bidders

2. Any Supplier may submit only one offer. 
3. Partial bids are not allowed. 
4. The offer should be prepared on the excel spreadsheet which constitutes Appendix 4 to this offer: Appendix_4 RFP 022897_Proposal [CompanyName]. If Appendix 4 is not filled out, the offer will not be considered. 
5. Offer along with the required attachments, may be submitted to the Adamed Procurement System at https://supplier.ariba.com or by e-mail: aleksandra.stojak(at)adamed.com. 
6. In addition, the Bidder may also prepare an offer in his own preferable format and uploaded into the system. 
7. Access to the Procurement System SAP Ariba Sourcing the Supplier obtains through the registration to verify the existence of the company. Basic information such as country, tax identification number, postal code, contact details, etc. should be provided. 
8. Supplier's Offer should be comprehensive in Polish or English, electronically. 
9. The offer should include at least the following information: supplier name, address, TAX / registry number, bid inquiry number, date of proposal, price net (PLN/EUR/USD).
10. If the prices in the offer are expressed in EUR they will be converted using the exchange rate of 4,4536 PLN/EUR, in accordance with the Notice of the President of the Public Procurement Office of 3 December 2021 on the current EU thresholds, their PLN equivalent, PLN equivalent of amounts expressed in EUR and the average PLN / EUR exchange rate constituting the basis for converting the value of public contracts or design contests. 
    In the case of another currency than PLN or EUR, the average NBP exchange rate from the last day of submitting offers will be accepted for conversion
11. Please attach filled and signed Checklist to confirm that all required documents will be delivered (Appendix no 5) 
12. Tenders submitted after the deadline will not be considered. 
13. The Supplier, before the deadline for submitting proposals, has the right to:
    1. withdraw the offer by submitting a written notification in the same way which is described for the submission of offers,
    2. change the offer - notification about the introduction of changes must be submitted according to the same rules as the offer submitted, appropriately marked with the annotation "CHANGE OF THE OFFER".

V. Selection criteria and evaluation methods:

1. The Contracting Authority is entitled to reject the tender submitted by the Supplier who does not meet the conditions for participation in the proceedings, or if the offer is incomplete or incompatible with this request.
2. Selection criteria:
   1. Net price (PLN/EUR/USD), the weight criterion - 100%, shall include all the associated costs.
3. The Contracting Authority shall evaluate offers based on the result of the accumulated number of points calculated on the basis of above criteria and scores:

   Criteria	Wieght criterion[%]	Method of evaluation in accordance with the formula
   Price net	100%	net price of the lowest offer / net price of the examined offer x 100 x 100% = number of points

4. The amounts of points for each criterion after summing up will be the final number of points awarded by each tender. As the most advantageous offer will be considered that which obtains the highest number of points. 
5. The results of the mathematical calculations carried out in the evaluation of tenders are rounded to the second decimal place. In case of equal scores for at least two offers the Contracting Authority will make the final choice of the offer more favorable when it comes to the impact on the environment (including the number of laboratory animals planned to use). For this purpose, the Contracting Authority shall have the right to call the Suppliers, whose tenders have obtained the highest final points, to complete the offer by giving indicated by the Contracting Authority information about an impact of the offer on the environment. The deadline to complete the offer will be determined by the Contracting Authority, but it cannot be less than 3 working days from receipt of the request. 

The choice of Supplier and way of announcing:

1. The Contracting Authority will select the most advantageous offer on the basis of the selection criteria defined in this request for proposal.
   The Contracting Authority will inform about the results of this request for proposal on website www.adamed.com.pl and will send to each Supplier which has submitted its offer

General provisions

1. The Offer shall be valid minimum 90 days.
2. The contracting authority reserves the right to cancel the procedure at any stage without giving any reason.
3. In the case of cancellation of the contract the Suppliers are not entitled to claim for reimbursement of the costs of participation in the proceedings.  
4. Submission of the application for registration in the process or tender is implies acceptance without reservation all the conditions of the proceedings. 
5. Withdrawal by the Contracting Authority from the conclusion of the contract after the notification the Supplier about the selecting the offer, cannot be the basis for claims of incurred costs of participation in the proceedings. 
6. In the process of evaluating Offers the Contracting Authority may seek information from the contractors concerning the content of their documents.  
7. If the application does not contain all the required elements, the Contracting Authority may in justified cases call the Supplier to complete it. 
8. The Contracting Authority reserves the right to record sound during technical meetings with suppliers. Submission of the offer will be treated as giving consent to the recording of the meeting. 
9. The Contracting Authority reserves the right to negotiate the proposal with the bidder, whose bid has the highest number of points, especially when the price offered by the bidder exceeds the budget intended by the Contracting Authority to perform the order. Negotiations may have several  consecutive  rounds  with  the  possibility  to  invite  bidder  to  submit  the updated quotation after each round of negotiations 
10. Terms of contract change: The contracting authority envisages the possibility of introducing significant changes to the contract concluded as a result of the conducted contract award procedure in relation to the content of the offer, on the basis of which the contractor was selected, in the event of the necessity to change the indicated scope of works specified in the offer: 
    1. Necessary or justified changes in the design documentation resulting from unforeseeable reasons, 
    2. The necessity or the technical-economic appropriateness of the use of equivalent materials and equipment, 
    3. The necessity to make equivalent solutions resulting from technological or utility conditions, 
    4. Financial constraints on the part of the Contracting Authority which cause the necessity to limit the scope of works included in the offer, 
    5. Necessary or justified changes in the delivery time and conditions of the contract subject resulting from unforeseeable reasons 

Any changes and additions to the contract concluded with the selected Supplier will be made in the form of written annexes to the contract signed by both parties, under rigor of invalidity. 

VIII. Additional information

1. Any questions should be submitted using the SAP Ariba Network or by e-mail: Aleksandra.Stojak(at)adamed.com, using Excel file (Appendix no 3)
2. Answers will be provided to all the participants via Procurement System SAP Ariba Network. 
3. The person authorized to contact the Suppliers on Monday-Friday from 08:00 am to 04:00 pm is: Aleksandra Stojak [aleksandra.stojak [at] adamed.com].

Appendix No 1  (download)

Appendix No 2  (download)

Appendix No 3  (download)

Appendix No 4  (download)

Appendix No 5  (download)

Supplier's instructions. Creating an offer on the Portal SAP Ariba Network (download)